Colorectal cancer (CRC) is a genetic disease with accumulated genetic alterations during the progression and invasion. CRC is highly aggressive and is the third leading malignance in the world population, and its incidence has been a health care challenge. Thus, there is an urgent need to identify more molecular biomarkers for CRC. Also, it is critical to explore the molecular mechanisms involv...
Aerobic glycolysis is considered a hallmark feature of cancer. Recently, Prof. Bin Wu's team from the Third Affiliated Hospital of Sun Yat-sen University published an original article entitled "Aerobic glycolysis enhances HBx-initiated hepatocellular carcinoma via NF-κBp65/HK2 signaling" online in the Journal of Experimental & Clinical Cancer Research on Nov. 21th, revealed a key mechanism of ...
Recently, the research team directed by Prof. Shicheng Su from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, revealed a new mechanism of the pro-tumor effect mediated by Fcγ receptor signals in non-leukocyte cells. This work entitled "CD16+ Fibroblasts Foster a Trastuzumab-Refractory Microenvironment That is Reversed by VAV2 Inhibition" was published online in Cancer Cell on Nov. 14th.
Recently, Prof. Kuang Ming's team (Center for Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University) and Prof. Lin Shuibin's team (Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University) co-published a research article entitled “Targeting tumor-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves...
Recently, Prof. Ming Kuang's research team from the First Affiliated Hospital, Sun Yat-sen University published a research paper entitled “METTL1-mediated m7G tRNA modification promotes lenvatinib resistance in hepatocellular carcinoma” online in Cancer Research, which deciphered novel mechanisms underlying lenvatinib resistance from a translation level perspective.
Recently, Professor Zhengqi Lu's group from the Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, published the latest original research entitled “FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation”in Autophagy. The study found that FOXP3+ macrophages suppressed acute ischemic stroke-in...
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